M80 is better for 0-4 armor situations, cuz on 0-3 armor level it does full 80 damage which should one-shot a body hit. This chart is probably worth printing, it shows you every caliber, but there is no way to sort it. It looses to M61 only when shooting level 6 armor. This one is updated very quickly and allows for you to select which caliber or gun you want to look at a compare. I like at the bottom it tells you who sells what bullets and the cost. Easy to use and it shows everthing on a grid. I use tarkov-tools for armor charts as well. Most players are running Class 1 to 3 armor sets, but you can almost say Class 3 armor is the most common due to the cost and how much protection you are getting. If you are running around customs going for scavs, grab the cheap stuff. If you are running Factory PvP raids, yes get the best bullet penetration you can. You need to use the right ammo that makes sense verse what you are up against. Now I completely disagree that you need use the best and most expensive ammo. Here are two links to reference to help figure out which ammo you should be using.